TFAM forces mtDNA to make a U-turn
نویسندگان
چکیده
منابع مشابه
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متن کاملCross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.
Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in controlling the transmission and expression of mtDNA. Nucleoid ultrastructure is poorly defined, and therefore we used a combination of biochemistry, superresolution microscopy, and electron microscopy to show that mitochondrial nucleoids have...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2011
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.2167